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The Role of Platelet-Rich Plasma (PRP) in Hair Transplantation

For many people, hair is an expression of personal style. If it has been an important part of your identity for much of your life, hair loss can cause a challenging situation for these people. For some people suffering from hair loss, platelet-rich plasma (PRP) injections, a medical approach called “PRP Treatment for Hair”, can eliminate your hair loss problem.

What is PRP Treatment?

PRP therapy is a treatment method that uses the patient’s own blood and has a simple application process. During this treatment, a small blood sample, usually taken from the arm area, is collected in a special tube and then centrifuged for 10 minutes. During the centrifugation process, the tube is rapidly spun and the plasma is separated from the red blood cells. This special plasma portion is then injected into the scalp with micro-needles.

What is the Effect of PRP on Hair Loss?

Platelet Rich Plasma (PRP) is a biological substance known for its high concentrations of more than 20 growth factors. These factors include platelet-derived growth factor, transforming growth factor, vascular endothelial growth factor (VEGF), epidermal growth factor, fibroblast growth factor, connective tissue growth factor and the insulin-like growth factor IGF-1.

These essential proteins promote extracellular matrix deposition by regulating cell migration, attachment, proliferation and differentiation. The growth factors in PRP promote hair regrowth by binding to relevant receptors expressed by stem cells of the hair follicle bulge zone and associated tissues.

Does PRP Grow Hair?

PRP application, with its effect on male pattern hair loss, raises the frequently asked question “Does PRP Grow Hair?”. The main purpose of PRP application is to regenerate damaged hair follicles and support their proliferation.

PRP does not have the ability to directly create new hair follicles. However, if there are dormant hair follicles with insufficient blood supply and support growth factors, the following effects of the growth factors contained in PRP can be observed:

Epidermal Growth Factor: Regulates hair cell growth and stimulates keratin and fiber production.

Transforming Growth Factor: Promotes the growth of new blood vessels by increasing the blood supply to the hair follicles.

Vascular Endothelial Growth Factor: Stimulates the growth of new blood vessels in the scalp.

Fibroblast Growth Factor: Provides effective repair of damaged hair follicles and supports tissue repair.

Platelet Derived Growth Factor: Supports collagen growth and proteoglycan synthesis, attracting macrophages and fibroblasts to the treated area.

Collagen Stimulating Growth Factor: Promotes the growth of healthy tissue and blood cells by stimulating granulocyte and macrophage proliferation.

Keratinocyte Growth Factor: Promotes new cell healing and formation by optimizing keratinocyte migration, differentiation and proliferation.

Interleukins, Macrophages, Keratinocytes, Endothelial Cells, Lymphocytes, Fibroblasts, Osteoblasts, Basophils and Mast Cells: It activates fibroblast differentiation into repair cells and also increases collagen and proteoglycan synthesis for healthy cell production and repair of damaged tissues.

PRP treatment with this rich content can be a solution to many people’s hair problems.

What are the Benefits of PRP Treatment?

PRP application against hair loss supports existing hair follicles as it provides nutrients for hair follicles and encourages the development of hair follicles that cannot grow due to malnutrition. This treatment, which is especially effective in the case of “male pattern hair loss”, prevents the hair follicles from shrinking and disappearing over time or slows down the process. In this case, the hair follicles have lost their ability to grow and only exist. PRP treatment for hair aims to break this cycle.

The plasma separated during PRP treatment for hair contains growth factors, a mixture of proteins and cytokines. These factors play an important role in contributing to hair growth by stimulating hair follicles.

The effects provided by the growth factors found in Hair PRP Treatment are as follows:

  • Epidermal Growth Factor: Regulates cell growth by stimulating keratin and fiber production.
  • Transforming Growth Factor: Promotes the growth of new blood vessels.
  • Vascular Endothelial Growth Factor: Stimulates the growth of blood vessels from the existing vasculature.
  • Fibroblast Growth Factor: Promotes granulation during tissue repair.
  • Platelet Derived Growth Factor: Promotes collagen growth and proteoglycan synthesis while attracting macrophages and fibroblasts to the treated area.
  • Collagen Stimulating Growth Factor: Stimulates granulocyte and macrophage proliferation for the growth of healthy tissue and blood cells.
  • Keratinocyte Growth Factor: Keratinocyte migration, differentiation and proliferations can optimize the conditions for healing and creation of new skin.
  • Interleukins, Macrophages, Keratinocytes, Endothelial Cells, Lymphocytes, Fibroblasts, Osteoblasts, Basophils and Mast Cells: Activates fibroblast differentiation and also induces collagen and proteoglycan synthesis for healthy cell production and repair of damaged tissues.

How is PRP Applied to Hair?

On the day of the PRP treatment, approximately 20cc of blood will be drawn and then placed in a centrifuge. During this time, the scalp is disinfected using spray disinfectants. The prepared PRP is injected into the scalp and the hair PRP application is completed.

Among people with hair loss, those with intact hair follicles are typically suitable candidates for PRP hair treatment. These patients may have excessive hair loss, but they are not completely bald, so the sooner a person with hair loss applies for hair PRP application, the more positive the results will be.

Men and women with hair loss problems are suitable candidates for PRP treatment for hair. The timing factor plays a critical role in PRP treatment for hair.

It is more beneficial to start PRP treatment for hair loss at the earliest possible stage. Generally, PRP treatment is started when baldness begins in men, while PRP treatment is requested when hair loss begins before baldness occurs in women.

PRP treatment is generally safe and can be applied to almost everyone. However, PRP treatment is not recommended in cases such as blood or platelet disease, active viral infection, steroid treatment or use of blood thinners.

During pregnancy, 40-50% of women may experience hair loss and thinning, but PRP is not performed during pregnancy. It is best to wait until after delivery for PRP treatment for hair during pregnancy.

PRP treatment for hair can usually be planned as 3-4 sessions once a month. It usually takes up to 6 months for the results to become evident. For PRP results to last longer, it is recommended to perform PRP treatment once a year. Depending on the severity of hair loss, 1-4 hair PRP treatments can be performed annually.

What should be considered before and after PRP Hair Treatment?

  • Hair should not be washed in the first 24 hours after PRP hair treatment and intense exercise should be avoided.
  • Hair care products should not be used for 24 hours after PRP hair treatment.
  • Excessive sun exposure to the treated area should be avoided for 48 hours after PRP hair treatment.
  • Sharp chemicals, hair dye or perm should not be applied to the hair for 72 hours after hair PRP.
  • Alcohol and smoking are not recommended in the first 72 hours after hair PRP.
  • Anti-inflammatory drugs should not be taken for five days after hair PRP treatment.
  • Blood thinners should not be taken for at least one week before and after PRP hair treatment.

Does Hair PRP Work?

Doctors and researchers at the University of Barcelona, Spain, have published their clinical findings on their six-year experience of using PRP for male pattern hair loss.

The results obtained after six PRP sessions for the treatment of androgenetic alopecia (male pattern hair loss) are as follows:

In the case of male pattern hair loss (androgenetic alopecia):

71.4% success rate was observed,

In 21.4% the condition remained the same.

In the case of male pattern hair loss (androgenetic alopecia) in women:

73.4% success rate was achieved,

For 16.3% the situation remained the same

Platelet Rich Plasma (PRP) plays an important role in hair transplantation. PRP is a plasma solution obtained from the patient’s own blood and contains a high concentration of platelets. By releasing growth factors, platelets can accelerate the healing process of hair follicles and stimulate hair growth. The use of PRP during hair transplantation can support the healing process, increase the chances of the transplanted hair follicles taking hold and promote healthier hair growth.

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